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  • Jul 1, 2026, 1:00 PM

    "It is, of course, an extraordinarily effective estrogenic agent, but that is the least of the problem. It is hypergolic with every known patient*, and so rapidly hypergolic that no induction period has ever been measured. It is also hypergolic with such things as syringes, examination tables, cotton wool, and nursing staff..."

    A photo of a small vial of Estradiol Trifluoride
    A section of text from the book Transition! An Informal History of Liquid Gender Affirmants. The text reads...

"All this sounds fairly academic and innocuous, but when translated into the problem of administering the stuff, the results are horrendous. It is, of course, an extraordinarily effective estrogenic agent, but that is the least of the problem. It is hypergolic with every known patient*, and so rapidly hypergolic that no induction period has ever been measured. It is also hypergolic with such things as syringes, examination tables, cotton wool, and nursing staff, not to mention saline, alcohol, and air. It can be kept in certain fluorinated polymers, provided they are not scratched, flexed, looked at sternly, or otherwise given an excuse to participate. * The only confirmed patient not only survived but lived to a comfortable old age. Throughout life she retained the ability to ignite combustible materials by touch. The medical significance of this observation remains uncertain, but the insurance implications were immediately obvious. She is on record as having ignited cigarettes, upholstery, and, on one occasion, an accountant. Apart from these inconveniences she remained in excellent health, and was generally agreed to have led a happy, if unusually vigorous, life."
    The cover to Transition! An Informal History of Liquid Gender Affirmants.
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