@altlazybear I don't think trustworthy is an applicable dimension for me most of the time. (Factual information should come with a source and/or I actually know the person and their credentials.)
I tend to stay away from accounts with >~1k followed because it starts to feel like commenting on a broadcast medium and not human interaction at that point. And I try to give accounts with <~10 followers the benefit of the doubt but will be quicker to disengage from them if it's not feeling fullfiling.
What I do often glance at, however, is the ratio of replies to boosts to original toots; phanpy helpfully displays this. I'm looking for thoughtful conversation. For that a balance of toots and replies with a sprinkle of boosts seems to often be a good sign.