@farbel @swope @nyrath Not with any number of the kind of bombs we've built to date.
(It's not ruled out by the laws of physics, but … once you get over about 100Mt yield, you run into the law of diminishing returns: most of the energy goes straight up into space, and meanwhile the "useful" energy that a given nuke releases doesn't go up linearly with yield.
Much more detail than you ever wanted to know on wikipedia: https://en.wikipedia.org/wiki/Effects_of_nuclear_explosions