@guenther as far as the actual audio signal goes, yes. But professional audio interfaces also provide sophisticated routing capabilities* which are not captured by USB audio class, but you got to configure somehow.
* for example: send and mix input 1 directly to output 4, which the headphone output 2 is monitoring, which goes to the headphones worn by the performer playing the instrument on input 1, so that they can hear their playing and the metronome coming from the DAW.