@fullywoolly You may also find the container feature (a window containing multiple window, with its own layout setting) useful.
When working at the desk with a large, wide monitor, I like using a two- or three-column (split-horizontally) top-level layout where every column contains multiple windows in a tabbed or split-vertically layout. When I take the laptop with me, the overall layout stays the same, I just convert those top-level horizontally-split top-level layouts to tabbed – the internal layout stays the same.
@cliffle