Genies go back in bottles, but miseries don't go back into Pandora's Box.

The pro-LLM crowd clearly mean to invoke that story rather than the genie. The box, after all, is a gift from the gods and they think they're building something divine.

"The misery can never be re-contained, but if you keep the box open, you'll find hope." is what they mean to say but can't because they can't admit to causing misery.