@hjakovel thanks for the tip. I checked and there are no conflicting directives from multiple config files (only one in my homedir actually exists), and turns out that variables that I set (prefix, etc) do apply correctly.
And the weirdest thing? If I manually run Prefix-: and run this statement, mouse support comes back! I think it might have to do with the execution order of the config file? If you don't mind, this is what I have (quite simple):
```
set -g prefix C-x
unbind C-b
bind C-x send-prefix
set -g default-terminal "screen-256color"
# this is nice (feels like a DE):
set -g mouse
# clock with a nicer color
setw -g clock-mode-colour green
```
(the clock pane does get its color changed)