@jameshowell @guix @daviwil
I’m going through the same process for about a month now.

I’m taking a different approach. Instead of outright replacing Debian, I started defining my Guix Home configuration first on Debian base. This is easier to experiment while still using a stable Debian base. I was able to move to Guix foreign install on both my work and home machines within the first week itself.

The Guix Info manuals are very useful.