@jameshowell @guix @daviwil I recommend an intermediate step: use guix as a package manager on top of Debian for a bit. This way you get to familiarize yourself with its logic while still having a usable system, and when you feel ready you can install the distro (you can even use the package manager to generate an installation iso with a custom configuration).

Alternatively, install the distro on a spare computer if you have one, so you can test all you want, make mistakes, etc. without causing downtime to your main computer.

Good luck, and enjoy! I found Guix super fun to explore and look forward to using it more when I have more free time.